A second big idea for having outsize impact with your giving is explore the unknown--to expand the base of human knowledge, Once a discovery is made it's a permanent expansion to the stock of human knowledge. That's a potential benefit for everyone, and great leverage for philanthropists who back these discoveries.
Some of the clearest examples involve medical research on curable diseases.
Take the "ice bucket challenge," for example.
This was a crowd sourced craze in 2014 on the internet. It raised $115 million to support ALS research in only 6 weeks. Those resources funded two breakthrough discoveries on previously unknown sources of the disease.
Another example is the Gates Foundation's support to develop a vaccine against malaria. It has been a long haul since Gates first announced $168m to support this effort in 2008. A billion dollars later, a vaccine that is over 70% effective in preventing childhood malaria is making its way through clinical trials.
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